This two-volume set constitutes reviewed and selected papers from the 12th International Advanced Computing Conference, IACC 2022, held in Hyderabad, India, in December 2022. The 72 full papers and 6 short papers presented in the volume were thorougly reviewed and selected from 415 submissions. The papers are organized in the following topical sections: ​AI in industrial applications; application of AI for disease classification and trend analysis; design of agricultural applications using AI; disease classification using CNN; innovations in AI; system security and communication using AI; use of AI in human psychology; use of AI in music and video industries.